Structural determinants of ion selectivity in brain calcium channel

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Structural determinants of calcium channel subunit function

L-, Nand P-lQ-type voltage-dependent calcium channels share a common structure, and are composed o f a t least one primary a, subunit and auxiliary P and a26 subunits. Expression o f the a, subunit alone in mammalian cells usually results in small calcium currents, and these are increased many times in amplitude by coexpression o f auxiliary P and a26 subunits. The P subunit, a cytoplasmically ...

متن کامل

Structural foundations of optogenetics: Determinants of channelrhodopsin ion selectivity.

The structure-guided design of chloride-conducting channelrhodopsins has illuminated mechanisms underlying ion selectivity of this remarkable family of light-activated ion channels. The first generation of chloride-conducting channelrhodopsins, guided in part by development of a structure-informed electrostatic model for pore selectivity, included both the introduction of amino acids with posit...

متن کامل

An Ingenious Filter: the Structural Basis for Ion Channel Selectivity

channel from Streptomyces lividans, was readily overex-pressed in bacteria (Schrempf et al., 1995). Its primary sequence is related to the class of ion-selective channels called inwardly rectifying channels, as evidenced by the presence of two putative transmembrane helices with the ion selectivity–determining P region residing Neurobiology has taken a giant step forward: we know, between them ...

متن کامل

Structural determinants of CaV1.3 L-type calcium channel gating

A C-terminal modulatory domain (CTM) tightly regulates the biophysical properties of Ca(v)1.3 L-type Ca(2+) channels, in particular the voltage dependence of activation (V(0.5)) and Ca(2+) dependent inactivation (CDI). A functional CTM is present in the long C-terminus of human and mouse Ca(v)1.3 (Ca(v)1.3(L)), but not in a rat long cDNA clone isolated from superior cervical ganglia neurons (rC...

متن کامل

Ion conduction and selectivity in acid-sensing ion channel 1

The ability of acid-sensing ion channels (ASICs) to discriminate among cations was assessed based on changes in conductance and reversal potential with ion substitution. Human ASIC1a was expressed in Xenopus laevis oocytes, and acid-induced currents were measured using two-electrode voltage clamp. Replacement of extracellular Na(+) with Li(+), K(+), Rb(+), or Cs(+) altered inward conductance an...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: FEBS Letters

سال: 1993

ISSN: 0014-5793

DOI: 10.1016/0014-5793(93)80009-j